Introducing the newest additions to the Mountcastle filler family: Refyne and Defyne.

By Dr. Timothy Mountcastle 

Two new fillers from the Galderma family are here! Adding two more fillers to the large list of fillers we already carry may add some confusion to choosing which best filler is right for you. If you are familiar with the Allergan family of fillers you know that includes Juvederm Ultra and Ultra plus, Juvederm Voluma, Juvederm Vollure, and Juvederm Volbella. Now with the Galderma family we have Restylane, Restylane Sylk, Restylane Lyft, Restylane Refyne, and Restylane Defyne.
So, what about these new fillers?

Restylane Refyne and Defyne serve very different purposes. They differ from all the other fillers in a sense that they are supposed to soften moderate laugh lines while still making your face look natural while talking and smiling. Some of the more hydrophilic fillers tend to look ‘puffy’ especially on patients who have thinner faces, so with these new fillers coming on the market it truly widens the possibilities.

Restylane Refyne

Restylane Refyne is used mainly for very superficial fine lines around the mouth. It creates a smooth softening of these pesky wrinkles, especially in motion. Restylane Refyne uses XpresHAn TechnologyTM which help to create the expressions in movement naturally and subtly.

Restylane Defyne

Restylane Defyne is used for deep nasolabial folds and marionette lines. Restylane Defyne also uses XpresHAn TechnologyTM which again creates volume and allows your expressions to look more natural than with some of the other thicker fillers.

Does it hurt?
Both fillers have lidocaine added for comfort. In some cases we can apply a topical numbing cream to help the injection be more comfortable. We also find that by holding ice before and after the injection it does help with any discomfort.

How long does it last?
As with any filler, it does depend on the patient. Normally these fillers should last 6-9 months, but some find it holds for longer. People who exercise regularly and have faster metabolisms tend to break these products down quicker.

Is there any downtime?

As with any injectable the biggest risk you take is bruising and swelling. Any time a needle is used to puncture the skin there is that possibility. In the event that a bruise does occur, it can last 7-10 days. Swelling usually subsides within 24-48 hours.

How do I know which filler is right for me?

The best thing to do is come in for a consultation where we can address your problem areas and lay out all the options you have. Below we have created a nice guide that may help you in making your decision as to which filler is right for you.

Restylane Family of Dermal Fillers Guide

Restylane L– Mostly used for lips and tear troughs

Restylane Sylk– Used for subtle lip enhancement and upper lip lines

Restylane Lyft– Used in the cheeks and malar region for cheek enhancement and to lift the midface off the jowls and nasolabial folds.

Restylane Defyne– Deep nasolabial folds or smile lines and marionette lines

Restylane Refyne– Very superficial etched in wrinkles around the mouth.


Timothy S. Mountcastle, M.D. is a Double Board Certified Plastic Surgeon, General Surgeon, and the Medical Director of Mountcastle Plastic Surgery & Vein Institute serving the Northern Virginia area. He is the Former Chief of Plastic Surgery at INOVA Loudoun Hospital and has been practicing aesthetic and reconstructive surgery since 2004. He serves as the Medical Director of the National Center for Veins and has offered advanced vein removal surgery since 1999. In 2014 and 2015.

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